1516 - 1862
------ | later

• 1516 - Curare - Peter Angherius (described)
• 1540 - Sweet Vitriol (Ether) Valerius Cordus
• 1628 - Circulation of blood - William Harvey
• 1657 - 1st IV injection - Boyle & Wren
• 1662 - Boyle’s Law - Robert Boyle
• 1665 - beast to beast blood transfusion - Lower
• 1751 - Anaesthesia defined “a defect of sensation” - Bailey’s English Dictionary
• 1754 - Carbon dioxide isolated - Black
• 1771 - Oxygen discovered - Priestley
• 1772 - Nitrous Oxide - Priestley
• 1788 - Tracheal intubation - Chas. Kite
• 1797 - Venturi tube - Giovanni Battista Venturi
• 1800 - analgesic properties of N2O - Davy
• 1800 - “Laughing Gas” - Davy
• 1806 - Morphine isolated in Hanover
• 1807 - Painless amputations using ice, on battlefields - Baron Larrey
• 1816 - Stethoscope - Rene Laennec
• 1817 - Narcotic effect of ether - Faraday
• 1824 - CO2 used for anaesthesia - Hickman
• 1831 - Chloroform discovered - several
• 1831 - Atropine prepared - Mein
• 1832 - IV saline infused for cholera - Latta
• 1843 - F.R.C.S. diploma established
• 1842 - Ether given for dental extraction - W.E.Clarke, Rochester & Crawford Long, Jefferson, Georgia.
• 1844 - Nitrous Oxide anaesthesia for dental extraction- Horace Wells
• 1846 - 'Letheon' anaesthesia demonstrated on Oct. 16th, Boston, Massachusetts- William T.G.Morton
• 1846 - 'Etherisation' defined as 'Anaesthesia' by Oliver Wendell Holmes.
• 1846 - Dec. 21st.: Liston amputated Fred Churchill’s leg under ether anaesthesia at UCH, London,
- Peter Squire was the anaesthetist.
• 1847 - John Snow's Ether Inhaler developed, exploiting sound physical principles
• 1847 - Anaesthetic properties of chloroform and ethyl chloride described in animals - Fluorens
• 1847 - Chloroform as an obstetric analgesic - James Young Simpson (Edinburgh)
• 1847 - “On the Inhalation of Ether in Surgical Operations” published. John Snow
• 1847 - 2 deaths recorded from use of ether
• 1848 - Ethyl Chloride used in humans
• 1853 - Glass syringe invented - Pravaz
• 1853 - John Snow gave chloroform to Queen Victoria “Chloroform a la reine”
• 1853 - Hypodermic syringe & needle invented - Alexander Wood
• 1855 - Cocaine isolated
• 1858 - John Snow published “On Chloroform & Other Anaesthetics.
• 1862 - Skinner developed the wire-frame fabric covered mask (Liverpool)
• 1862 - Clover’s chloroform inhaler
• 1862 - ACE mixture (alcohol 1 pt., chloroform 2 pts, ether 3 pts.) - Harley